Oct 17, 2025
3 min read
A study published in Nature shows that autism diagnosed in childhood is genetically different from autism diagnosed in adolescence or adulthood.
Even though the DSC-2 in 2015 with this change, The contraction, has been free, not only in the number of diseases.
Today, the umbrella of autism includes people with normal intellectual abilities and language, as well as others with severe developmental disabilities or severe comorbidities such as epilepsy.The most obvious cases are usually detected in early childhood, while others are identified later in adulthood.
A complex disorder without a single cause
Autism is a complex neurodegenerative disorder of multidisciplinary origin.Although some genetic and environmental factors have been described, there is no reason to explain them.
Now, a new study published in the journal Emergency, a researcher: ASD is different from children with unusual cognitive abilities later in life.
According to the authors, it shows that it is not one or the same uniform, but different situations that share some common characteristics.
Twice on the spectrum
Warrier's team analyzed genetic and developmental data from more than 45,000 individuals from four birth cohorts and multiple international databases.The results showed clear differences between those diagnosed before age 7 and those diagnosed later.
The former - those diagnosed in early childhood - were more likely to present with global developmental delay and intellectual disabilities, as well as significant difficulties with motor and language milestones.In contrast, those diagnosed at later stages showed typical initial development, but over time began to manifest more subtle cognitive and behavioral difficulties.
Genetic variations and associated diseases
At the genetic level, the differences are also striking.Children are tested at an early age when deformities are shown and genetic variation is limited, with small differences spread across many different genes.
Additionally, those with advanced diagnoses were more likely to have other comorbidities, such as attention-deficit/hyperactivity disorder (ADHD), depression, and post-traumatic stress disorder (PTSD).Interestingly, their genetic makeup was more similar to this disorder than to early-onset autism.
The moment of diagnosis is an important part
For a caregiver, these are not aware of the most common and important things from the reporting of the Case of the Moticom of the Austic Autism, it is added to know for a whole year.
However, the researchers explain that the specific genetic variants that characterize each profile have not yet been identified. According to Turner, the next step will be to understand the interaction between genetic and social causes, which may explain why some people receive a diagnosis much later.
The study also acknowledges that social factors, such as access to health services, early access to services or lack of early detection, may influence delays in diagnosis rather than just biological reasons.
Experts Speak: Towards a New Understanding of Autism
Cambridge's work has sparked reactions from experts around the world. Elliot Tucker-Dob, a professor of psychology at the University of Texas at Austin, believes the study provides evidence that the time of diagnosis may be one of the keys to distinguishing between subtypes of ASD."It's possible, if not unlikely, that there are other subtypes that haven't been identified," he said.
For him, the researcher Etartarvien, the famous Endes, at the University College in London, warns that "the real question that is said, which is known in the future.
People have many faces
Although the authors indicate that there is a need to replicate the results in a more diverse population, the study published in Nature reinforces the idea that autism encompasses a variety of phenomena with different causes, trajectories and consequences.
Ultimately, these results not only challenge the traditional view of autism as a single disorder, but also open a single door to the innism and flompality that is on the spectrum and the complex that is on the spectrum and the spectrum and the spectrum and vice versa.
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